ODM-204, a Novel Dual Inhibitor of CYP17A1 and Androgen Receptor: Early Results from Phase I Dose Escalation in Men with Castration-resistant Prostate

Drs Philippa Cheetham and Glen Gejerman define castration-resistant prostate cancer and provide an overview of emerging treatments that may improve outcomes

Subheadings: analysis anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology Castration-resistant prostate cancer (CRPC) with castrate level of serum testosterone. Prostate-specific Antigen (PSA) doubling time of ≤ 10 months and PSA > 2ng/ml. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. metastatic castration-resistant prostate cancer (mCRPC), and historically the median survival for men with mCRPC has been less than two years.

Castration resistant

Single-center, prospective, non controlled, open label, phase II trial. The main objective of this study is to evaluate the Disease Control Rate (DCR) and the safety as co-primary objective. AstraZeneca today announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy designation (BTD) for the oral poly ADP-ribose polymerase (PARP) inhibitor Lynparza™ (olaparib), for the monotherapy treatment of BRCA1/2 or ATM gene mutated metastatic Castration Resistant Prostate Cancer (mCRPC) in patients who have received a prior taxane-based chemotherapy and at 2019-07-30 · Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole-genome RNA sequencing, gene set enrichment analysis, and immunohistochemistry.

Radiometabolic Therapy (RMT) with 177Lu PSMA 617 in advanced castration resistant prostate cancer (CRPC): efficacy and toxicity evaluation.

2020-03-31 · Castration-resistant prostate cancer: Treatments targeting the androgen pathway Chemotherapy in advanced castration-resistant prostate cancer Coronavirus disease 2019 (COVID-19): Cancer screening, diagnosis, treatment, and posttreatment surveillance in uninfected patients during the pandemic

The majority of patients with systemic prostate cancer treated with androgen deprivation therapy (ADT) will develop castration-resistant prostate cancer (CRPC). CRPC is defined by prostate-specific antigen (PSA) or radiographic progression in the context of castrate levels of testosterone.[1]

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1 Development of prostate cancer is … 2018-06-01 Administration of docetaxel every 2 weeks seems to be well tolerated in patients with castration-resistant advanced prostate cancer and could be a useful option when 3-weekly single-dose administration is unlikely to be tolerated. Radiometabolic Therapy (RMT) with 177Lu PSMA 617 in advanced castration resistant prostate cancer (CRPC): efficacy and toxicity evaluation. Single-center, prospective, non controlled, open label, phase II trial. The main objective of this study is to evaluate the Disease Control Rate (DCR) and the safety as co-primary objective.

These cancers are called castration-resistant, because they no longer respond to hormonal castration treatment. In this type of cancer, the level of prostate-specific antigen (PSA) in the blood rises again. The doctor will diagnose castration-resistant prostate cancer if repeated tests Castration-resistant prostate cancers are a class of cancer that do not respond to first-line treatments, which include surgery and/or a standard hormone treatment called androgen-deprivation therapy (ADT). Castration Resistant Prostate Cancer CRPC is defined as biochemical and/or clinical progression despite castrate levels of testosterone and presents as a continuous rise in serum PSA levels, progression of pre-existing disease, or metastases [1].
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Data suggests that 10-20% of patients with prostate cancer metastasis develop castration-resistant prostate cancer (CRPC) within 5 years of follow-up, and that the median survival since development of castration resistance is approximately 14 months (range 9-30). For non-metastatic castration-resistant prostate cancer, recent phase III placebo-controlled trials with enzalutamide, apalutamide and darolutamide all demonstrated benefits in improving metastasis-free survival.

The aim of this study was to 2020-02-24 · However, an increasingly recognized proportion of tumors develop histologic transformation to a castration-resistant neuroendocrine prostate cancer (CRPC-NE) phenotype as a mechanism of AR-independent treatment resistance (3 – 5).
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Tumor-educated platelets for early prostate cancer diagnosis, and therapy stratification in patients with metastasized castration resistant prostate cancer.

Castration Resistant Prostate Cancer CRPC is defined as biochemical and/or clinical progression despite castrate levels of testosterone and presents as a continuous rise in serum PSA levels, progression of pre-existing disease, or metastases [1]. Advanced castration-resistant prostate cancer (CRPC) is when cancer of the prostate has metastasized, (spread to other parts of the body), despite hormone therapies being given to limit the male hormones, or androgens, in the body.