Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270).

13010 Ensembl ENSG00000101439 ENSMUSG00000027447 UniProt P01034 P21460 RefSeq (mRNA) NM_001288614 NM_000099 NM_009976 RefSeq (protein) NP_000090 NP_001275543 NP_034106 Location (UCSC) Chr 20: 23.63 – 23.64 Mb Chr 2: 148.87 – 148.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic

Each month, FTD members receive exclusive offers and discounts on a variety of products. Check out the latest FTD Marketplace catalogs and promotions that can help you save money. Current Catalogs & Promotions are enclosed in the FTD Clearinghouse Statement. PDBe › 5m9r.

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Europe PMC is an archive of life sciences journal literature. Intracellular organelles do not, as thought for a long time, act in isolation but are dynamically tethered together by entire machines responsible for inter-organelle trafficking and positioning. 14824 Ensembl ENSG00000030582 ENSMUSG00000034708 UniProt P28799 P28798 RefSeq (mRNA) NM_001012479 NM_002087 NM_008175 RefSeq (protein) NP_002078 NP_032201 Location (UCSC) Chr 17: 44.35 – 44.35 Mb Chr 11: 102.43 – 102.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Granulin the solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human 19164 Ensembl ENSG00000080815 ENSMUSG00000019969 UniProt P49768 P49769 RefSeq (mRNA) NM_000021 NM_007318 NM_007319 NM_008943 NM_001362271 RefSeq (protein) NP_000012 NP_015557 NP_001349200 Location (UCSC) Chr 14: 73.14 – 73.22 Mb Chr 12: 83.69 – 83.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders.

Solution NMR Linking hnRNP Function to ALS and FTD Pathology. Purice et al. (2018) 7 more.

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders.

Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. (PMID: 21944778) DeJesus-Hernandez M … Rademakers R (Neuron 2011) 2 3 4 74; C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. (PMID: 24549040) Farg MA … SWISS-MODEL Repository entry for P28799 (GRN_HUMAN), Progranulin. Homo sapiens (Human) 13010 Ensembl ENSG00000101439 ENSMUSG00000027447 UniProt P01034 P21460 RefSeq (mRNA) NM_001288614 NM_000099 NM_009976 RefSeq (protein) NP_000090 NP_001275543 NP_034106 Location (UCSC) Chr 20: 23.63 – 23.64 Mb Chr 2: 148.87 – 148.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic SWISS-MODEL Repository entry for A0A3N4FTD4 (A0A3N4FTD4_BURML), Dihydroxy-acid dehydratase.

Granulin is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor progranulin, a 593 amino acid long and 68.5 kDa protein. While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis.

Presenilin-1 is a presenilin protein that in humans is encoded by the PSEN1 gene. Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta from amyloid precursor protein. Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. (PMID: 21944778) DeJesus-Hernandez M … Rademakers R (Neuron 2011) 2 3 4 74; C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. (PMID: 24549040) Farg MA … SWISS-MODEL Repository entry for P28799 (GRN_HUMAN), Progranulin. Homo sapiens (Human) 13010 Ensembl ENSG00000101439 ENSMUSG00000027447 UniProt P01034 P21460 RefSeq (mRNA) NM_001288614 NM_000099 NM_009976 RefSeq (protein) NP_000090 NP_001275543 NP_034106 Location (UCSC) Chr 20: 23.63 – 23.64 Mb Chr 2: 148.87 – 148.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic SWISS-MODEL Repository entry for A0A3N4FTD4 (A0A3N4FTD4_BURML), Dihydroxy-acid dehydratase. Burkholderia mallei (Pseudomonas mallei) Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping.Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone.

It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalize metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19 protein. CYP2C19 is a liver enzyme that acts on at least 10% of drugs … Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
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Granulin is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor progranulin, a 593 amino acid long and 68.5 kDa protein. While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis.

Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta from amyloid precursor protein. Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. (PMID: 21944778) DeJesus-Hernandez M … Rademakers R (Neuron 2011) 2 3 4 74; C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
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What is Frontotemporal Degeneration (FTD)?